Prolonged gastric mucosal haemorrhage following azacitidine administration in a patient with myelodysplastic syndrome
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Disseminated varicella-zoster virus infection following azacitidine in a patient with myelodysplastic syndrome.
June 2009 • Volume 13, Number 3 • Clinical Journal of Oncology Nursing Guiyun Zhou, MSN, CRNP, AOCNS®, is a nurse practitioner at Vita Hematology Oncology in Bethlehem, PA, and a doctoral student in the Jefferson School of Nursing at Thomas Jefferson University in Philadelphia, PA; and Arlene D. Houldin, PhD, PMHCNS-BC, is an associate professor in the School of Nursing at the University of Pen...
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Granulocytic sarcoma (GS) is an uncommon and localized extramedullary tumor composed of immature granulocytic cells. Most GS reported in large series were not associated with overt acute myelogenous leukemia. Gastric perforation occurred during prednisolone therapy in a 72-year-old Japanese male with a four-month history of a myelofibrosis-like state. Subtotal gastrectomy was performed for a su...
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Eosinophilic pneumonia is characterized by cough, lung infiltrates on imaging, and by the presence of eosinophils in the alveoli and pulmonary interstitium. Azacitidine, a pyramidine nucleoside analog of cytidine, is FDA approved for the treatment of various myelodysplastic syndromes. We present a case of a 76-year-old man with recently diagnosed myelodysplastic syndrome, who developed eosinop...
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Azacitidine is a first-in-class demethylating agent, and it is widely used globally as a first-line treatment for higher-risk myelodysplastic syndrome (MDS). Here, we report the case of a patient with MDS who suffered from a rare adverse event, an acute lung injury (ALI), which was suspected to have been caused by azacitidine and was successfully treated with corticosteroids. As it is a rare, b...
متن کاملDNA Methylation Changes Following 5-azacitidine Treatment in Patients with Myelodysplastic Syndrome
DNA methyltransferase inhibitor, 5-azacitidine (AC) is effective in myelodysplastic syndromes (MDS) and can induce re-expression in cancer. We analyzed the methylation of 25 tumor suppressor genes in AC-treated MDS. Hypermethylation of CDKN2B, FHIT, ESR1, and IGSF4 gene was detected in 9/44 patients. In concordance with the clinical response, a lack of or decreased methylation in 4 patients wit...
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ژورنال
عنوان ژورنال: eJHaem
سال: 2021
ISSN: 2688-6146,2688-6146
DOI: 10.1002/jha2.206